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References Eli Lilly and Company

Serious side effects of the medication include the following: Allergic or hypersensitivity reaction Severe gastrointestinal issues Changes in mood and behavior Pancreatitis Liver problems Low blood sugar levels (hypoglycemia) Cardiac arrhythmias Suicidal ideation Major depressive disorder No adverse event of hypoglycemia or thyroid cancer was reported in Phase II trials, and 7% of retatrutide participants had skin sensitivity, compared to 1% on placebo, but these cases were not serious

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Theoretically, yes

You may have some residual soreness around the treatment area after your appointment, but this should fade away within a few hours